Freeze Containers

Bridging Time and Distance

The validated alternative to freezing in plastic bags.

Freeze & Thaw Systems

Single Use Freezing – The Challenge:

The biopharmaceutical sector needs flexibility to respond to momentary demand and supply, distribute production steps between locations, and hold intermediate forms of products for some time
between processing steps.  This makes it essential to have a method of storing and transporting sensitive products such as pharmaceutical proteins.  ZETA is a Global leading in such large scale freeze/Thaw technology.  However the industry is also in need of smaller scale freeze containers in various sizes to safely store, freeze and recover these very expensive and potent molecules.  Freezing in single use bags has not proven viable for many in our industry which led ZETA, in cooperation with several Global customers to develop these small scale containers.

Single Use Freezing – The Solution for many is not in plastic!

10, 20, 50 ml Containers

ZETA 10, 20 and 50 ml FreezeContainers are ideal for transport and storage of aseptic liquids. They have proven their usefulness in stability studies and storage of reserve samples of active pharmaceutical ingredients (APIs).  ZETA 10, 20, and 50 ml FreezeContainers are equipped with 2-inch tri-clamp openings.

ZETA 10ml, 20ml and 50ml Freeze Bottles

The design of the containers makes them easy to clean, and they stand steadily by themselves.

  • Stainless steel 1.4435
  • Traceability by means of full documentation of lots, with certificate management
  • Lot and serial numbers etched on every container
  • Ra<0.4µm/<1.2µm electropolished surfaces (inside and outside)
  • Delta ferrite content of material limited to 1%
  • Lid made of 1.4435 with tri-clamp connections
  • USP Class VI certificates including statements on BSE/TSE for gaskets
  • Optional: EPDM, Silicone, Teflon or blue Gylon gaskets

1L and 5L Containers

ZETA 1 and 5L FreezeContainers have 4-inch tri-clamp ports. They are used in pharmaceutical processes for storage and transport of processed sterile liquids in liquid or frozen form.

Zeta 1 and 5 liter Freeze Bottles
  • Stainless steel 1.4435
  • Traceability by means of full documentation of lots, with certificate management
  • Lot and serial numbers etched on every container
  • Ra<0.4µm/<1.2µm electropolished surfaces (inside and outside)
  • Delta ferrite content of material limited to 1% in base material and  < 3% in welds
  • Lid made of 1.4435 with 2 filling ports, with tri-clamp connections
  • USP Class VI certificates including statements on BSE/TSE for gaskets
  • Optional: EPDM, Silicone, Teflon or blue Gylon gaskets

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Since the exact freezing conditions are critical for avoiding damage to the product, product-specific development of the freezing method is key to success. Zeta Freeze & Thaw Systems are a family of equipment that offer you an economical, logical and reliable path from initial lab experiments through pilot scale to full production volumes of 10 to 300 l.

Zeta LabFreeze System

Investigative apparatus for initial studies of protein-specific behavior with a working volume of 200 ml.
The Zeta LabFreeze is made for initial experiments and maximizes the amount of data you can obtain from a very small volume of product.
It can deliver first insights into effects such as cold denaturation, cryoconcentration, pH shifts and surface stresses. This data can be used to model the freezing process for the specific product and to derive starting conditions for the next stage of testing.

Zeta PilotFreeze System
Miniature Industry-Grade system for testing process methods with a standard working of 700ml. Higher volume units are possible.
The Zeta PilotFreeze is a step up to a miniature version of the production-grade system. It allows closer simulation of the production process and further refinement of the method. This stage minimizes unpredictable effects when you move up to full production scale.

Zeta FreezeSystem

Production-scale system for freezing, transporting and thawing with a working volume of up to 300 liters.

FreezeThaw System Scale-up
FreezeThaw System Scale-up

Expert Support

The dynamics of the freezing process hold significant risks for product quality. However, with a careful and logical approach to process design, these risks can be controlled. Zeta Freeze & Thaw Systems offer you a safe path through the development of product-specific freezing and thawing processes.

Scaling up the process is guided by Zeta FreezeSimulation, a process modeling solution that makes each step in development more predictable and also provides a basis for Quality by Design (QbD), opening up the possibility of abbreviated validation of the freezing process.

Zeta Freeze & Thaw Systems come with full backup in the form of an expert support and development service. Our experienced team of experts in biotechnology and bioprocess engineering can guide you through experimentation, modeling and optimization of process parameters and can also support you in carrying out protein stability studies.

Advantages of Stainless Steel

Safe, reliable, robust
Free of leachables and extractables
Long operational life
Ideal process control with inline and online sensors